In New York, researchers at the National Human Genome Research Institute conducted a genomic study showing mutation similarities between clear cell endometrial cancer and other endometrial carcinomas. The genome sequence data they pulled found over 20 genes that were frequently mutated in endometrial cancer. Daphne Bell, a lead cancer genetics and comparative genomics researcher on the project, told GenomeWeb, “Because the cancer is often diagnosed after it has spread beyond the uterus, the mortality rate is unacceptably high. We’re trying to build a knowledge base to decipher the fundamental genomic changes that drive these cancers.” Their hope with this new knowledge is to better detect endometrial cancer in future patients based on their genetic profile before it’s too late.
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