The Digest’s 2026 Multi-Slide Guide to Feedstock-Efficient Biomanufacturing

This guide presents a breakthrough in decoupling energy generation from carbon metabolism in E. coli. By engineered expression of oxygen-tolerant hydrogenase and formate dehydrogenase, researchers achieved 86% and 98% efficiency in replacing acetate oxidation with external electron donors. The most newsworthy result is a 57.6% boost in mevalonate titers. This metabolic rewiring allows microbes to conserve feedstock carbon for product synthesis rather than burning it for energy, significantly reducing production costs and CO2 emissions.