By Sam A. Rushing, Advanced Cryogenics, Ltd. Special to The Digest Flue gas is the most prevalent source of CO2 off-gas from all processes globally; among the lion’s share of this flue gas is the ever – present electric power plant, primarily fueled by coal, and then secondly, natural gas. The CO2 found in coal […]
In Florida, The Daily Digest announced the Bioeconomy 500 for 2026, recognizing 500 individuals whose leadership is helping transform the bioeconomy from scientific and commercial possibility into projects, products and industries. The honorees span the full architecture of the advanced bioeconomy: scientists and engineers, entrepreneurs and executives, project developers and operators, financiers, policy leaders, feedstock […]
The choice between single-use and stainless-steel systems at commercial scale is a fundamental capability commitment, not a simple capital expenditure decision. Single-use technology eliminates cleaning validation but introduces heavy supply chain dependencies, vendor concentration risks, and consumable qualification requirements. Conversely, stainless systems require rigorous cleaning validation, dead-leg management, and zoning discipline to control in-house contamination. […]
In Florida, the Daily Digest announced the 50 Hottest Companies in the Bioeconomy for 2026, as voted by the Digest’s readers and invited selectors. For the first time, EVERY took the #1 slot in the annual poll. Avantium takes the #2 position, followed by LanzaTech at #3, Strategic Biofuels at #4 and Itaconix at #5. […]
Modern biorefineries must transition from obsolete single-source models to multi-feedstock portfolio aggregation to survive. This capability unlocks an estimated twenty to thirty-five percent margin advantage through optimized acquisition economics, carbon-intensity revenue from LCFS and 45Z policies, and improved process performance. To avoid the “cheap-feedstock trap” where contaminants erode margin advantages, leaders must invest in robust […]
This week, Again announced the acquisition of Genomatica, uniting Again’s cutting-edge biomanufacturing scale-up capabilities with Geno’s world-class AI discovery and design platform. So, Rome bought Greece. That is one way to think about Again’s acquisition of Genomatica, announced this week, bringing together one of industrial biotechnology’s most ambitious new scale-up companies with one of its […]
Continuous fermentation offers capital-intensity advantages over batch systems above five hundred cubic meters, but realizing these economics depends entirely on sustained run length. Hardware availability and regulatory frameworks like ICH Q13 are no longer the bottleneck; the true constraint is internal operating discipline. Operators must avoid applying batch habits to continuous hardware. Achieving economic viability […]
Contamination is an operating system, not an isolated event, demanding proactive systemic management. While chronic Lactobacillus infections act as an invisible tax diverting 1% to 5% of sugars, catastrophic contamination events can lead to nine-figure financial disasters. Scale-up from pilot to commercial volumes amplifies these risks. To suppress contamination, leaders must build integrated systems combining […]
Bioprocess data is strategic infrastructure, but raw data without context is expensive noise. While most operators collect basic historian and LIMS signals, they suffer from delayed, manual data reconstruction. True competitive advantage requires building a “contextualized operating history” by binding process signals to batches, materials, and events at write-time. This governed data architecture accelerates investigations, […]
Fort Drum Service Plaza sits an hour southeast of Disney World along the Florida Turnpike, marked by a statue of Mickey Mouse that has signaled to a generation of children that the Magic Kingdom is near. At seven-fifteen in the morning, it plays host to what must surely be the longest line for Dunkin’ coffee […]
