Tufts researchers expand use of bacterial spores as catalysts to produce fuels
In Texas, a remarkable quality of bioengineering is that scientists can take biological processes honed by millions of years of evolution and use them to efficiently create drugs, chemicals and other products to improve our lives. Now Tufts researchers have found new ways to expand the potential for using bacterial spores as catalysts for chemical reactions, biofuel production or breaking down pollutants.
When some species of bacteria find themselves in an environmentally stressful situation like extreme heat, cold, aridity, loss of nutrients or even exposure to disinfectants, they can hunker down and form spores—hardened, protein-coated spheres protecting a DNA-filled core. The spores remain stable and dormant for years—even centuries—waiting patiently until the right conditions allow them to resurrect into active bacteria once again.
This extraordinary stability has made bacterial spores strong candidates for bioengineering. Researchers are designing spores to express drugs, industrial enzymes and catalysts, and to be used as biological sensors, as useful molecules are fused to the spore’s outer coat of proteins. The products fused to the proteins can be stored and distributed without the need for refrigeration or can be used in applications under extreme conditions, such as high heat or exposure to harsh chemicals.
Category: Research
