The Digest’s 2024 Multi-Slide Guide to Downstream Processing (DSP) in biomanufacturing

This presentation deck, presented at the ABLC NEXT Conference, outlines the importance of downstream processing (DSP) in biomanufacturing, particularly for the development and production of biopharmaceuticals. The author, a lead bioprocess engineer, highlights DSP’s significant impact on project cost, quality, and overall success. It emphasizes that a “one size fits all” approach is not feasible and that product characteristics, including purity, stability, and cost, drive process selection. The presentation deck delves into various DSP considerations, including the need for careful characterization of impurities, the scale-up from lab to commercial production, and the selection of appropriate unit operations based on product type. It also underscores the importance of collaboration with upstream processes to minimize impurities and maximize product titer.