Pomegranate extract could help bacteria lose resistance to silver nanoparticles

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In the Czech Republic, a unique mechanism that enables bacteria to defend themselves against silver nanoparticles has been discovered by scientists at Palacký University. This mechanism does not require the bacteria to undergo genetic changes, and differs significantly from mechanisms of antibiotic resistance. The scientists have also found a way to suppress bacterial resistance to nanosilver, which could be crucial in addressing the global antibiotics crisis.

Scientists and physicians have been unable to determine whether repeated exposure to nanoparticles can cause bacteria to develop resistance similar to that seen with antibiotics. After approximately five years of work, this question has been answered by researchers.

“Resistance can be easily overcome by adding substances that suppress the formation and release of flagellin. Suitable substances are found in pomegranate extracts, among other things. If such extracts are applied together with silver nanoparticles, the bacteria do not produce flagellin and therefore lose their resistance to silver nanoparticles,” explained Libor Kvítek from RCPTM, who has pioneered nanosilver research in Olomouc.