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March 09, 2009 | Jim Lane | Comments 1

Biofuels pioneer makes synthetic “cell engine”; first step towards artificial life

Ribosome image produced by produced by Harry Noller at the University of California Santa Cruz, Venki Ramakrishnan at the University of Cambridge, England, and Thomas Steitz at Yale University, as seen on NOVA

Ribosome image produced by produced by Harry Noller at the University of California Santa Cruz, Venki Ramakrishnan at the University of Cambridge, England, and Thomas Steitz at Yale University, as seen on NOVA

In Massachusetts, the co-founder of advanced biofuels producer LS9, Professor George Church of Harvard Medical School, said that his two-man research team at Harvard had synthesized an artificial ribosome, a “biological machine” or “cell engine” that is found in every living organism and is the biological manufacturer of proteins.

The breakthrough makes possible the development of new, artificial “designer” enzymes for cellulosic breakdown, as well the as the possibility of artificial life itself. Church downplayed the “artificial life” angle himself in comments with reporters, saying only that it was only an important step in that direction, that a ribosome was an essential component in a synthetic life form.

However, the researchers have developed a means of synthetically replicating proteins in lab dishes, and successfully synthesized luciferase, the protein that causes fireflies to glow, in a test. A potential benefit of such study is the development of cellular life that contains higher lipid or starch content for biofuel production, or converts a higher range of light wavelengths to plant energy and competes with solar thin-film photovoltaic cells in solar efficiency.

The breakthrough has not yet been reported in peer-reviewed academic journals, and is part of Church’s Harvard research, not IP owned by LS9.

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